Resource Type

Journal Article 46

Year

2023 3

2022 3

2021 2

2020 4

2019 7

2018 3

2017 5

2016 5

2015 1

2014 4

2013 1

2011 2

2010 1

2009 1

2001 1

1999 1

open ︾

Keywords

animal models 4

animal husbandry 3

animal model 2

embryo 2

feed industry 2

genome editing 2

manure management 2

Escherichia coli 1

Escherichia coli Laos 1

blaNDM-5 1

mcr 1

Animal manure 1

Animal nutrition 1

Antimicrobial resistance transmission 1

Aquaculture 1

Artificial bear bile 1

B-cell acute lymphoblastic leukemia 1

BGB-A445 1

Bioactive compound 1

open ︾

Search scope:

排序： Display mode:

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Engineering 2017, Volume 3, Issue 1,   Pages 28-35 doi: 10.1016/J.ENG.2017.01.010

Abstract: The statuses of preclinical animal investigations and of the clinical translation of engineered cartilage

Keywords： Cartilage tissue engineering     Preclinical immunocompetent animal     investigation     Clinical translation     Orthopedic    

HTML PDF Collect

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Engineering doi: 10.1016/j.eng.2023.09.017

Abstract: Comprehensive preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effectsFurthermore, preclinical toxicological assessment and phase Ⅰ clinical trials show that the safety of

Keywords： Artificial bear bile     Chemical profile     Formula optimization     Pharmacodynamic consistency     Preclinical toxicological    

HTML PDF Collect

human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells: a preclinical

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract: In this study, we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

HTML PDF Collect

non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activation and also promotes dendritic cells to mature to enhance their cytokine production. Therefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interest. However, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy. Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation, induced optimal T cell activation without impairing dendritic cell function. In addition, BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity. In the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibody showed antitumor efficacy characterized by a hook effect. Furthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody. Taken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast to clinical-stage anti-OX40 antibodies, shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

HTML PDF Collect

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

HTML PDF Collect

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 123-128 doi: 10.15302/J-FASE-2019309

Abstract: power to alter DNA sequences at chosen genomic loci, thereby generating various genetically edited animalthe development of major genome editing tools, focusing on the application of these tools to generate animal

Keywords： animal model     CRISPR     genome editing     TALEN     ZFN    

HTML PDF Collect

Cryopreservation of farm animal gametes and embryos: recent updates and progress

Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 42-53 doi: 10.15302/J-FASE-2018231

Abstract:

Cryopreservation has undergone tremendous advances and is widely used in animal production based on

Keywords： vitrification     gametes     embryo     animal production     cryoprotective agent     freezability    

HTML PDF Collect

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are requiredretain the histological and genetic features of their donor tumors have been shown to be the preferred preclinicaltool in translational cancer research compared with other conventional preclinical models.In this paper, we discuss the establishment, characterization, and preclinical applications of the PDXAlthough various limitations still exist, this preclinical approach should be further tested and improved

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral squamous cell carcinoma    

HTML PDF Collect

The speciation, leachability and bioaccessibility of Cu and Zn in animal manure-derived biochar: effect

Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian

Frontiers of Environmental Science & Engineering 2017, Volume 11, Issue 3, doi: 10.1007/s11783-017-0924-8

Abstract: Biochars derived from animal manures may accumulate potentially toxic metals and cause a potential risk

Keywords： Animal manure     Biochar     Metals     Molecular species     Pyrolysis    

HTML PDF Collect

Highlights of special issue on Animal Science

Jun REN

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 257-259 doi: 10.15302/J-FASE-2017165

HTML PDF Collect

Antimicrobial use in food animal production: situation analysis and contributing factors

Ziping WU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 301-311 doi: 10.15302/J-FASE-2018207

Abstract: antimicrobial use at farm level, this study discusses the main knowledge gaps in antimicrobial use in food animalFactors associated with animal health (including antimicrobial resistance), animal health improvement, economic costs and benefits relevant to animal diseases, and potential technological alternatives or

Keywords： antimicrobial use     drivers for antimicrobial use     food animal production    

HTML PDF Collect

Electrolyzed water and its application in animal houses

Weichao ZHENG,Li NI,Baoming LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 195-205 doi: 10.15302/J-FASE-2016109

Abstract: its production, there is reduced corrosion of surfaces and it minimizes the potential for damage to animallast decade, EW has become increasingly popular as an alternative disinfectant for decontamination in animalantimicrobial mecha- nism of EW, and recent developments related to the application of SAEW and NEW in animal

Keywords： disinfection     poultry and livestock     slightly acidic electrolyzed water     neutral electrolyzed water    

HTML PDF Collect

Animal stem cells: the engineering development front of 2018

Wenye YUAN, Jianxiang XU, Chenying LI, Lijuan SHI, Aidong YANG, Yan WANG, Lu XING, Shaozhong KANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 93-95 doi: 10.15302/J-FASE-2018250

HTML PDF Collect

Polar Animal Genetic Resources: Current Situation and Development Strategies

Chen Songlin, Xu Wenteng, Chen Zhangfan

Strategic Study of CAE 2019, Volume 21, Issue 6,   Pages 39-47 doi: 10.15302/J-SSCAE-2019.06.007

Abstract:

This article has reviewed the current status of polar animal genetic resources and proposed the developmentThe late initiation in the study of polar animal genetic resources limited its current depth and width

Keywords： polar animal     genome     transcriptome     genetic resources    

HTML PDF Collect

Comparison of analytical procedures for measuring phosphorus content of animal manures in China

Guohua LI, Qian LIU, Haigang LI, Fusuo ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 4,   Pages 431-440 doi: 10.15302/J-FASE-2019279

Abstract: There is considerable regional variation in animal manure P across China, which needs to be considered

Keywords： diet phosphorus     manure phosphorus     sequential P fractionation    

HTML PDF Collect

Title Author Date Type Operation

Recent Progress in Cartilage Tissue Engineering—Our Experience and Future Directions

Yu Liu, Guangdong Zhou, Yilin Cao

Journal Article

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Journal Article

human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells: a preclinical

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical

Journal Article

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Journal Article

A brief review of genome editing technology for generating animal models

Haoyi WANG, Sen WU, Mario R. CAPECCHI, Rudolf JAENISCH

Journal Article

Cryopreservation of farm animal gametes and embryos: recent updates and progress

Zhengyuan HUANG, Lei GAO, Yunpeng HOU, Shien ZHU, Xiangwei FU

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

The speciation, leachability and bioaccessibility of Cu and Zn in animal manure-derived biochar: effect

Qi Lin, Xin Xu, Lihua, Wang, Qian Chen, Jing Fang, Xiaodong Shen, Liping Lou, Guangming Tian

Journal Article

Highlights of special issue on Animal Science

Jun REN

Journal Article

Antimicrobial use in food animal production: situation analysis and contributing factors

Ziping WU

Journal Article

Electrolyzed water and its application in animal houses

Weichao ZHENG,Li NI,Baoming LI

Journal Article

Animal stem cells: the engineering development front of 2018

Wenye YUAN, Jianxiang XU, Chenying LI, Lijuan SHI, Aidong YANG, Yan WANG, Lu XING, Shaozhong KANG

Journal Article

Polar Animal Genetic Resources: Current Situation and Development Strategies

Chen Songlin, Xu Wenteng, Chen Zhangfan

Journal Article

Comparison of analytical procedures for measuring phosphorus content of animal manures in China

Guohua LI, Qian LIU, Haigang LI, Fusuo ZHANG

Journal Article